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Article

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.

Molecular cell - 5 Nov 2015

Schwab Rebekka A, Nieminuszczy Jadwiga, Shah Fenil, Langton Jamie, Lopez Martinez David, Liang Chih-Chao, Cohn Martin A, Gibbons Richard J, Deans Andrew J, Niedzwiedz Wojciech

Abstract excerpt

DNA replication stress can cause chromosomal instability and tumor progression. One key pathway that counteracts replication stress and promotes faithful DNA replication consists of the Fanconi anemia (FA) proteins. However, how these proteins limit replication stress remains largely elusive. Here we show that conflicts between replication and transcription activate the FA pathway. Inhibition of transcription or...

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Source

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Identifiers

PMID: 26593718
DOI: 10.1016/j.molcel.2015.09.012
PMCID: PMC4644232

Genes

FANCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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