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R-loops acted on by RNase H1 are a determinant of chromosome length-associated DNA replication timing and genome stability in <i>Leishmania</i>

2024-05-01

Abstract excerpt

Genomes in eukaryotes normally undergo DNA replication in a choreographed temporal order, resulting in early and late replicating chromosome compartments. Leishmania , a human protozoan parasite, displays an unconventional DNA replication program in which the timing of DNA replication completion is chromosome size-dependent: larger chromosomes complete replication later then smaller ones. Here we show that both R...

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Literature Corpus work
f5512b3e-3e41-5020-bc6f-36446aa25a90
DOI
10.1101/2024.04.29.591643
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R-loops acted on by RNase H1 are a determinant of chromosome length-associated DNA replication timing and genome stability in <i>Leishmania</i>DOI 10.1101/2024.04.29.591643
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