Article

Overexpression of miR-424(322)/-503 Induces Severe Dilated Cardiomyopathy by Regulating The Fatty Acid Oxidation Gene Expression Program

2026-08-18

Abstract excerpt

Fatty acid oxidation (FAO) is a major energy source in the adult heart, and disruption of cardiac metabolism is closely associated with heart failure. Here, we investigated the effects of cardiac-specific overexpression of the H19X-encoded miR-424(322)/-503 cluster using an inducible transgenic mouse model. Sustained miR-424(322)/-503 overexpression caused rapid metabolic and functional deterioration, with early i...

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Literature Corpus work: 87300519-0738-5b71-96fb-3a8068a015ca
DOI: 10.64898/2026.08.17.744731

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