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Article

Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.

Cardiovascular research - 1 Aug 2018

van Weeghel Michel, Abdurrachim Desiree, Nederlof Rianne, Argmann Carmen A, Houtkooper Riekelt H, Hagen Jacob, Nabben Miranda, Denis Simone, Ciapaite Jolita, Kolwicz Stephen C, Lopaschuk Gary D, Auwerx Johan, Nicolay Klaas, Des Rosiers Christine, Wanders Ronald J, Zuurbier Coert J, Prompers Jeanine J, Houten Sander M

Abstract excerpt

Aims: Mitochondrial fatty acid oxidation (FAO) is an important energy provider for cardiac work and changes in cardiac substrate preference are associated with different heart diseases. Carnitine palmitoyltransferase 1B (CPT1B) is thought to perform the rate limiting enzyme step in FAO and is inhibited by malonyl-CoA. The role of CPT1B in cardiac metabolism has been addressed by inhibiting or decreasing CPT1B...

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Share to Carnitine O-Palmitoyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29635338
DOI: 10.1093/cvr/cvy089

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