Nuclear miR-320 Mediates Diabetes-Induced Cardiac Dysfunction by Activating Transcription of Fatty Acid Metabolic Genes to Cause Lipotoxicity in the Heart

Abstract excerpt

Rationale: Diabetes mellitus is often associated with cardiovascular complications, which is the leading cause of morbidity and mortality among patients with diabetes mellitus, but little is known about the mechanism that connects diabetes mellitus to the development of cardiovascular dysfunction. Objective: We aim to elucidate the mechanism underlying hyperglycemia-induced cardiac dysfunction on a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiovascular Function and Risk Factors
• Share to MicroRNA in disease regulation
• Share to Peroxisome Proliferator-Activated Receptors