Article

Conditional deletion of CEACAM1 causes hepatic stellate cell activation

2024-04-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Hepatic CEACAM1 expression declines with advanced hepatic fibrosis stage in patients with MASH. Global and hepatocyte-specific deletions of Ceacam1 impair insulin clearance to cause hepatic insulin resistance and steatosis. They also cause hepatic inflammation and fibrosis, a condition characterized by excessive collagen production from activated hepatic stellate cells (HSC...

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Literature Corpus work: 87116632-e77b-5027-90d6-609ef8cb9530
DOI: 10.1101/2024.04.02.586238

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