Article

Fibrotic Phenotype in CRISPR knockout p53 of Hepatic Organoids within a Pro-Carcinogenic Microenvironment

2024-03-05

Abstract excerpt

<title>Abstract</title> <p>Hepatic fibrogenesis is a pathological outcome of chronic liver injury, characterized by the excessive accumulation of extracellular matrix proteins, leading to hepatocarcinogenesis. However, the lack of reliable models that mimic precancerous fibrogenesis in the early stage of the disease remains a significant obstacle. Here, we utilized human pluripotent stem cell-derived hepatic orga...

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Literature Corpus work: d0f96404-a167-5ec8-a626-288fd263e970
DOI: 10.21203/rs.3.rs-3935080/v1

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