Article

KRAS withdrawal in Cholangiocarcinoma leads to immune infiltration and tumor regression

2025-06-17

Abstract excerpt

<h4>Background and Aims</h4> Cholangiocarcinoma (CCA) is a liver cancer with poor survival rates. Current treatments, including targeted therapies for specific mutations, are limited and benefit only a small subset of patients. KRAS mutations are found in 15-40% of CCA, representing a new potential treatment target. Whether KRAS inhibition leads to CCA tumor regression is unknown partly due to the lack of condit...

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Literature Corpus work: 961c23b5-bccf-5e4b-a2b2-acb024f472d4
DOI: 10.1101/2025.06.11.659210

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