Article

Distinct structural transitions of chromatin topological domains coordinate hormone-induced gene regulation

2014-03-13

Abstract excerpt

The human genome is segmented into Topologically Associating Domains (TADs), but the role of this conserved organization during transient changes in gene expression is not known. Here we described the distribution of Progestin-induced chromatin modifications and changes in transcriptional activity over TADs in T47D breast cancer cells. Using ChIP-Seq, Hi-C and 3D modelling techniques, we found that the borders of...

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Literature Corpus work: 786666e3-1b84-5367-b56e-8dd7bcd69917
DOI: 10.1101/003293

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