Article

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

2020-10-21

Abstract excerpt

Comparing transcript levels between healthy and diseased individuals allows the identification of differentially expressed genes, which may be causes, consequences or mere correlates of the disease under scrutiny. Here, we propose a bi-directional Transcriptome-Wide Mendelian Randomization (TWMR) approach that integrates summary-level data from GWAS and whole-blood eQTLs in a MR framework to investigate the causal...

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Literature Corpus work: 86f11d44-c3e7-5382-aecf-d80f0ce5584f
DOI: 10.1101/2020.10.19.20213538

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