Article

An alternative framework for transcriptome-wide association studies to detect and decipher gene-trait associations

2025-03-17

Abstract excerpt

Transcriptome-wide association studies (TWAS) are widely used to uncover transcriptomic mechanisms underlying disease. Here, we present VINTAGE, an alternative TWAS framework designed to identify and decipher gene-trait associations through two complementary tests: a genetic variance test that generalizes TWAS and unifies it with SKAT, offering a clearer understanding of TWAS false signals when expression is not r...

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Literature Corpus work: 27b697d8-3bc1-54ea-9fe1-e5185d64a94e
DOI: 10.1101/2025.03.14.643391

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