Article

Whole Genome DNA and RNA Sequencing of Whole Blood Elucidates the Genetic Architecture of Gene Expression Underlying a Wide Range of Diseases

2022-05-31

Abstract excerpt

To create a scientific resource of expression quantitative trail loci (eQTL), we conducted a genome-wide association study (GWAS) using genotypes obtained from whole genome sequencing (WGS) of DNA and gene expression levels from RNA sequencing (RNA-seq) of whole blood in 2622 participants in Framingham Heart Study. We identified 6,778,286 cis -eQTL variant-gene transcript (eGene) pairs at p < 5x10 − 8 (2,855,111...

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Literature Corpus work: ac7e5b89-bbeb-5c02-8878-92d3a13e8578
DOI: 10.21203/rs.3.rs-1598646/v1

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