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Article

Multi-trait transcriptome-wide association studies with probabilistic Mendelian randomization.

American journal of human genetics - 4 Feb 2021

Liu Lu, Zeng Ping, Xue Fuzhong, Yuan Zhongshang, Zhou Xiang

Abstract excerpt

A transcriptome-wide association study (TWAS) integrates data from genome-wide association studies and gene expression mapping studies for investigating the gene regulatory mechanisms underlying diseases. Existing TWAS methods are primarily univariate in nature, focusing on analyzing one outcome trait at a time. However, many complex traits are correlated with each other and share a common genetic basis....

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Identifiers

PMID: 33434493
DOI: 10.1016/j.ajhg.2020.12.006
PMCID: PMC7895847

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