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Mendelian Randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

2018-07-25

Abstract excerpt

Genome-wide association studies (GWAS) identified thousands of variants associated with complex traits, but their biological interpretation often remains unclear. Most of these variants overlap with expression QTLs (eQTLs), indicating their potential involvement in the regulation of gene expression. Here, we propose an advanced transcriptome-wide summary statistics-based Mendelian Randomization approach (called TW...

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Literature Corpus work
6425adf8-1201-568b-934f-cedcc0cbf16a
DOI
10.1101/377267
Open publication

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Mendelian Randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traitsDOI 10.1101/377267
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