Article

Quantifying the impact of genetically regulated expression on complex traits and diseases

2019-02-11

Abstract excerpt

About 90% of risk variants identified from genome-wide association studies (GWAS) are located in non-coding regions, highlighting the regulatory role of genetic variants. We propose a unified statistical framework, IGREX, for quantifying the impact of genetically regulated expression (GREX). This is achieved by estimating proportion of phenotypic variations that can be explained by the GREX component. IGREX only r...

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Literature Corpus work: 78963a59-8583-501e-bf7a-9a351faed807
DOI: 10.1101/546580

Open publication

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