Article
Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome.
Nature communications - 24 Sept 2021
Porcu Eleonora, Sadler Marie C, Lepik Kaido, Auwerx Chiara, Wood Andrew R, Weihs Antoine, Sleiman Maroun S Bou, Ribeiro Diogo M, Bandinelli Stefania, Tanaka Toshiko, Nauck Matthias, Völker Uwe, Delaneau Olivier, Metspalu Andres, Teumer Alexander, Frayling Timothy, Santoni Federico A, Reymond Alexandre, Kutalik Zoltán
Abstract excerpt
Comparing transcript levels between healthy and diseased individuals allows the identification of differentially expressed genes, which may be causes, consequences or mere correlates of the disease under scrutiny. We propose a method to decompose the observational correlation between gene expression and phenotypes driven by confounders, forward- and reverse causal effects. The bi-directional causal effects...
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