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The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomes

26 Nov 2024

Abstract excerpt

Herpes simplex virus 1 (HSV-1) latently infected neurons display diverse patterns in the distribution of the viral genomes within the nucleus. A key pattern involves quiescent HSV-1 genomes sequestered in promyelocytic leukemia nuclear bodies (PML NBs) forming viral DNA-containing PML-NBs (vDCP NBs). Using a cellular model that replicates vDCP NB formation, we previously demonstrated that these viral genomes are...

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PMID: 39589886
DOI: 10.1073/pnas.2412258121

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