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The HUSH-SETDB1-MORC2 epigenetic repressor complex restricts herpesvirus infection in association with PML nuclear bodies

2023-02-07

Abstract excerpt

<title>Abstract</title> <p>The establishment of latent herpes simplex virus 1 (HSV-1) infection is controlled by promyelocytic leukemia nuclear bodies (PML NBs). Viral genomes are recruited to PML NBs structures and chromatinized by repressive H3.3K9me3 modified H3.3 histone variant to form viral DNA-containing PML-NBs (vDCP NBs). Exactly how this occurs is unclear. Here we identify an essential role for the HUSH...

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Literature Corpus work
526300de-d3d9-51e8-98fe-ad5715904d71
DOI
10.21203/rs.3.rs-2521252/v1
Open publication

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The HUSH-SETDB1-MORC2 epigenetic repressor complex restricts herpesvirus infection in association with PML nuclear bodiesDOI 10.21203/rs.3.rs-2521252/v1
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