Article

Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in infection

2023-02-07

Abstract excerpt

Innate immune responses are crucial for limiting virus infection. However, viruses often hijack our best defenses for viral objectives. Human Cytomegalovirus (HCMV) is a beta herpesvirus which establishes a life-long latent infection. Defining the virus-host interactions controlling latency and reactivation is vital to the control of viral disease risk posed by virus reactivation. We defined an interaction between...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 175b5063-49bf-57e9-9bbe-01bf9c9e4bde
DOI: 10.1101/2023.02.07.527452

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in infectionDOI 10.1101/2023.02.07.527452Read

Human cytomegalovirus regulates host DNA repair machinery for viral genome integritySemantic proximity Read

Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from LatencySemantic proximity Read

High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion MechanismsSemantic proximity Read

Analysis of the ubiquitin-modified proteome identifies novel host factors in Kaposi’s sarcoma herpesvirus lytic reactivationSemantic proximity Read

UL135 and UL136 Epistasis Controls Reactivation of Human CytomegalovirusSemantic proximity Read

The BTK-DDX41 axis of the STING pathway is activated during cytomegalovirus lytic infectionSemantic proximity Read

Proteomic Profiling of the Human Cytomegalovirus UL35 Gene Products Reveals a Role for UL35 in the DNA Repair ResponseSemantic proximity Read

LXR-inducible host E3 ligase IDOL targets a human cytomegalovirus reactivation determinantSemantic proximity Read

Emerging insights into HAUSP (USP7) in physiology, cancer and other diseasesSemantic proximity Read

Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7.Semantic proximity Read

Regulation of EBNA1 Protein Stability by PLOD1 Lysine HydroxylaseSemantic proximity Read

Viral and host network analysis of the human cytomegalovirus transcriptome in latencySemantic proximity Read