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Article

Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.

Neurobiology of disease - 1 Aug 2022

Kluss Jillian H, Bonet-Ponce Luis, Lewis Patrick A, Cookson Mark R

Abstract excerpt

Coding mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene, which are associated with dominantly inherited Parkinson's disease (PD), lead to an increased activity of the encoded LRRK2 protein kinase. As such, kinase inhibitors are being considered as therapeutic agents for PD. It is therefore of interest to understand the mechanism(s) by which LRRK2 is activated during cellular signaling. Lysosomal...

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Identifiers

PMID: 35580815
DOI: 10.1016/j.nbd.2022.105769
PMCID: PMC9665168

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