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Article

LRRK2 mediated Rab8a phosphorylation promotes lipid storage.

Lipids in health and disease - 27 Feb 2018

Yu Miao, Arshad Muhammad, Wang Wenmin, Zhao Dongyu, Xu Li, Zhou Linkang

Abstract excerpt

BACKGROUND: Several mutations in leucine rich repeat kinase 2 (LRRK2) gene have been associated with pathogenesis of Parkinson's disease (PD), a neurodegenerative disorder marked by resting tremors, and rigidity, leading to Postural instability. It has been revealed that mutations that lead to an increase of kinase activity of LRRK2 protein are significantly associated with PD pathogenesis. Recent studies have...

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Identifiers

PMID: 29482628
DOI: 10.1186/s12944-018-0684-x
PMCID: PMC5828482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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LRRK2 mediated Rab8a phosphorylation promotes lipid storage.PMID 29482628Read ↗

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