Article
Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease.
Biochemical Society transactions - 15 Dec 2016
Cookson Mark R
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, associated with Parkinson's disease, have been shown to affect intracellular trafficking pathways in a variety of cells and organisms. An emerging theme is that LRRK2 can bind to multiple membranous structures in cells, and several recent studies have suggested that the Rab family of small GTPases might be important in controlling the recruitment of...
Topics
- Autophagy
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Lysosomes
- Models, Biological
- Mutation
- Parkinson Disease
- Protein Transport
- Transport Vesicles
- rab GTP-Binding Proteins