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Article

The genome-wide mutational consequences of DNA hypomethylation.

Scientific reports - 27 Apr 2023

Besselink Nicolle, Keijer Janneke, Vermeulen Carlo, Boymans Sander, de Ridder Jeroen, van Hoeck Arne, Cuppen Edwin, Kuijk Ewart

Abstract excerpt

DNA methylation is important for establishing and maintaining cell identity and for genomic stability. This is achieved by regulating the accessibility of regulatory and transcriptional elements and the compaction of subtelomeric, centromeric, and other inactive genomic regions. Carcinogenesis is accompanied by a global loss in DNA methylation, which facilitates the transformation of cells. Cancer hypomethylation...

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Identifiers

PMID: 37106015
DOI: 10.1038/s41598-023-33932-3
PMCID: PMC10140063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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