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Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer

1 Jan 2014

Abstract excerpt

Cancer is a leading cause of death worldwide. Aberrant promoter hypermethylation of CpG islands associated with tumor suppressor genes can lead to transcriptional silencing and result in tumorigenesis. DNA methyltransferases (DNMTs) are the enzymes responsible for DNA methylation and have been reported to be over-expressed in various cancers. This review highlights the current status of transcriptional and...

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PMID: 25949795
DOI: 10.1186/2045-3701-4-46

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