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Article

Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing.

Blood cells, molecules & diseases - 1 Mar 2018

Banaszak Lauren G, Giudice Valentina, Zhao Xin, Wu Zhijie, Gao Shouguo, Hosokawa Kohei, Keyvanfar Keyvan, Townsley Danielle M, Gutierrez-Rodrigues Fernanda, Fernandez Ibanez Maria Del Pilar, Kajigaya Sachiko, Young Neal S

Abstract excerpt

DNA methyltransferase 3A (DNMT3A) mediates de novo DNA methylation. Mutations in DNMT3A are associated with hematological malignancies, most frequently acute myeloid leukemia. DNMT3A mutations are hypothesized to establish a pre-leukemic state, rendering cells vulnerable to secondary oncogenic mutations and malignant transformation. However, the mechanisms by which DNMT3A mutations contribute to leukemogenesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29324392
DOI: 10.1016/j.bcmd.2017.12.002
PMCID: PMC6728079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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