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Article

Alterations to DNMT3A in Hematologic Malignancies.

Cancer research - 15 Jan 2021

Venugopal Kartika, Feng Yang, Shabashvili Daniil, Guryanova Olga A

Abstract excerpt

In the last decade, large-scale genomic studies in patients with hematologic malignancies identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de novo DNA methyltransferase DNMT3A has emerged as one of the most frequently mutated genes in adult myeloid as well as lymphoid malignancies and in clonal hematopoiesis. In this review, we discuss recent advances in our understanding of...

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Share to Acute Myeloid Leukemia Research
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Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

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Source

Open in PubMed Open full text

Identifiers

PMID: 33087320
DOI: 10.1158/0008-5472.CAN-20-3033
PMCID: PMC7855745

Genes

DNMT3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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