Article

Comparison of PU.1 genomic binding across immune cells reveals cell type-specific roles in autoimmune disease

2026-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Transcription factors play key roles in cellular biology. Their genomic binding events are enriched at disease- and trait-associated genetic risk loci in particular cellular contexts. To examine this phenomenon in depth, we constructed a PU.1 (SPI1) binding atlas by uniformly processing 260 PU.1 ChIP-seq datasets spanning many immune cell types. Comparison of ChIP-seq peaks across eight major im...

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Literature Corpus work: 8619f2fb-bd49-54f9-b3b5-db9e8a41f642
DOI: 10.64898/2026.01.26.26344838

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