Article

Colocalization of blood cell traits GWAS associations and variation in PU.1 genomic occupancy prioritizes causal noncoding regulatory variants

2023-03-30

Abstract excerpt

Genome-wide association studies (GWAS) have uncovered numerous trait-associated loci across the human genome, most of which are located in noncoding regions, making interpretations difficult. Moreover, causal variants are hard to statistically fine-map at many loci because of widespread linkage disequilibrium. To address this challenge, we present a strategy utilizing transcription factor (TF) binding quantitative...

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Literature Corpus work: 2fccf08f-0a44-5baa-a3ae-b9089823b397
DOI: 10.1101/2023.03.29.534582

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