Article

Variation in PU.1 binding and chromatin looping at neutrophil enhancers influences autoimmune disease susceptibility

2019-04-29

Abstract excerpt

Neutrophils play fundamental roles in innate inflammatory response, shape adaptive immunity 1 , and have been identified as a potentially causal cell type underpinning genetic associations with immune system traits and diseases 2,3 The majority of these variants are non-coding and the underlying mechanisms are not fully understood. Here, we profiled the binding of one of the principal myeloid transcriptional reg...

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Literature Corpus work: 2acd44a7-b388-5961-9a1b-8a6569fefdc2
DOI: 10.1101/620260

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