Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases

25 Feb 2019

Abstract excerpt

Several Genome Wide Association Studies (GWAS) have reported variants associated to immune diseases. However, the identified variants are rarely the drivers of the associations and the molecular mechanisms behind the genetic contributions remain poorly understood. ChIP-seq data for TFs and histone modifications provide snapshots of protein-DNA interactions allowing the identification of heterozygous SNPs showing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic factors in colorectal cancer
Share to Genomic variations and chromosomal abnormalities
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30804403
DOI: 10.1038/s41598-019-39633-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseasesPMID 30804403Read ↗

Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease riskSemantic proximity Read ↗

Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs.Semantic proximity Read ↗

In vivo measurement and prediction of cell-type-resolved non-coding variant effects in human immunitySemantic proximity Read ↗

Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms.Semantic proximity Read ↗

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritabilitySemantic proximity Read ↗

Landscape of allele-specific transcription factor binding in the human genomeSemantic proximity Read ↗

Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.Semantic proximity Read ↗

Genetic variation in cis-regulatory domains suggests cell type-specific regulatory mechanisms in immunity.Semantic proximity Read ↗

Allele-specific binding (ASB) analyzer for annotation of allele-specific binding SNPs.Semantic proximity Read ↗

Landscape of allele-specific transcription factor binding in the human genome.Semantic proximity Read ↗

3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibilitySemantic proximity Read ↗

find-tfbs: a tool to identify functional non-coding variants associated with complex human traits using open chromatin maps and phased whole-genome sequencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.