Article

Integration of chromatin accessibility and gene expression data with cisREAD reveals a switch from PU.1/SPIB-driven to AP-1-driven gene regulation during B cell activation

2023-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Human B cell differentiation into antibody secreting plasma cells is a critical process in the adaptive immune response, whose regulation at the genetic level remains incompletely understood. To reveal the temporal sequence of transcription factor driven cellular changes we generated chromatin accessibility (ATAC-seq) and gene expression (RNA-seq) data from in vitro differentiation of human B c...

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Literature Corpus work: 4ce5295b-3adf-5e58-b398-2b370ba8b0b0
DOI: 10.1101/2023.01.09.522862

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Integration of chromatin accessibility and gene expression data with cisREAD reveals a switch from PU.1/SPIB-driven to AP-1-driven gene regulation during B cell activationDOI 10.1101/2023.01.09.522862Read

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