Article

Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation

2025-05-03

Abstract excerpt

Lamin A/C ( LMNA ), a key component of the nuclear envelope, is essential for maintaining nuclear integrity and genome organization [1]. While LMNA dysregulation has been implicated in genomic instability across cancer and aging, the underlying mechanisms remain poorly understood [2]. Here, we investigate LMNA ’s role in small-cell lung cancer (SCLC), a highly aggressive malignancy characterized by extreme geno...

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Literature Corpus work: 85e9eda0-ffff-5e52-8cc4-83a853ec5574
DOI: 10.1101/2025.04.29.651052

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