Article

PRC2 loss impairs small cell lung cancer tumorigenesis and enhances sensitivity to G9a/GLP inhibition

2025-03-31

Abstract excerpt

<title>Abstract</title> <p>Effective targeted therapies for small cell lung cancer (SCLC) remain a significant challenge. Targeting the epigenome to overcome immune evasion and chemoresistance represents a promising strategy to improve treatment outcomes. In this study, we explored the role of Polycomb repressive complex 2 (PRC2), a key transcriptional repressor, by dissecting its structural and enzymatic functio...

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Literature Corpus work: 1054e793-bc3e-5e72-b296-0a1ca4ada2e9
DOI: 10.21203/rs.3.rs-5952196/v1

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