Article

Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small-Cell Lung Cancer

2026-07-31

Abstract excerpt

<h4>Background</h4> Small-cell lung cancer (SCLC) is characterized by pervasive chromosomal instability (CIN) and remains largely refractory to targeted therapies. KIF18A, a motor protein that regulates chromosome alignment during mitosis, has emerged as a selective dependency in CIN-high tumors. Whether this dependency extends to SCLC, a prototypical CIN-high cancer, has not been established, and biomarkers pred...

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Literature Corpus work: e151ef42-136e-5c6b-8348-c4bb59f20983
DOI: 10.64898/2026.07.30.741836

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