Article
Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells.
Oncotarget - 20 Oct 2015
Nardella Marta, Guglielmi Loredana, Musa Carla, Iannetti Ilaria, Maresca Giovanna, Amendola Donatella, Porru Manuela, Carico Elisabetta, Sessa Giuseppe, Camerlingo Rosalba, Dominici Carlo, Megiorni Francesca, Milan Marika, Bearzi Claudia, Rizzi Roberto, Pirozzi Giuseppe, Leonetti Carlo, Bucci Barbara, Mercanti Delio, Felsani Armando, D'Agnano Igea
Abstract excerpt
Tumor-initiating cells constitute a population within a tumor mass that shares properties with normal stem cells and is considered responsible for therapy failure in many cancers. We have previously demonstrated that knockdown of the nuclear envelope component Lamin A/C in human neuroblastoma cells inhibits retinoic acid-mediated differentiation and results in a more aggressive phenotype. In addition, Lamin A/C...
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