Article

EZH2 Inhibition Reshapes 3D Chromatin Architecture to Induce Immunogenic Phenotype in Small Cell Lung Cancer

2026-01-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The histone methyltransferase EZH2, enzymatic core of the trimeric polycomb repressive complex 2 (PRC2), has been shown to promote small cell lung cancer (SCLC) survival through epigenetic silencing of multiple targets including Class I MHC molecules ( HLA-A/B ) and DNA repair factors ( SLFN11 ). Treatment of SCLC cells with EZH2 inhibitors in vitro can reactivate express...

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Literature Corpus work: 33a6e207-853b-5a7c-baeb-576be95f4d1e
DOI: 10.64898/2026.01.26.701784

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