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Article

Organoid-based modeling unveils Dnmt3a-driven epigenetic regulation of phenotypic plasticity in small cell lung cancer.

Cancer letters - 10 Jul 2026

Liu Liansheng, Wu Qingzhe, Fang Shuxian, Hu Zengyong, Yu Shicheng, Wang Hailong, Song Hai, Liu Qian

Abstract excerpt

Small cell lung cancer (SCLC) harbors pronounced intratumoral heterogeneity, yet epigenetic drivers of subtype plasticity remain poorly understood. Herein, we established paired neuroendocrine (NE)-high and NE-low SCLC organoids from pulmonary neuroendocrine cells (PNECs)-specific Trp53/Rb1/Pten-triple knockout mice. NE-high organoids developed prominent axon-like protrusions, while NE-low counterparts exhibited...

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Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to Endogenous Retroviruses

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 42000030
DOI: 10.1016/j.canlet.2026.218516

Genes

CARM1
DNMT3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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