Article

Lamin A/C maintains genome topology and regulates transcriptional programs essential for virus-driven B cell activation

2026-01-13

Abstract excerpt

<h4>ABSTRACT</h4> Lamin A/C is a crucial structural component of the nuclear lamina that influences chromatin organization and gene regulation. In this study, we demonstrate that lamin A/C is vital for maintaining higher-order genome organization and transcriptional programs that support EBV-driven B-cell activation. Loss of lamin A/C in a B-lymphoblastoid cell line caused significant three-dimensional reorganiza...

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Literature Corpus work: 0137e2db-9519-5a5b-9c23-39e4331c2973
DOI: 10.64898/2026.01.12.699161

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