Article

Lamin A/C safeguards replication initiation by orchestrating chromatin accessibility and PCNA recruitment

2025-03-11

Abstract excerpt

Lamin A/C, a nuclear lamina protein, is essential for maintaining nuclear architecture, organizing chromatin and preserving genomic stability. However, its role in regulating DNA replication remains unclear. This study investigates how Lamin A/C regulates proper activation of replication origins by orchestrating the chromatin structure and recruitment of proliferating cell nuclear antigen (PCNA). We demonstrate th...

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Literature Corpus work: daad1d26-da5e-5ca3-b9d0-dc2ee585b10b
DOI: 10.1101/2025.03.06.641818

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