Article

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

2022-02-19

Abstract excerpt

<h4>Summary</h4> Aging is characterized by gradual immune dysfunction and increased risk for many diseases, including respiratory infections. Genomic instability is thought to play a central role in the aging process but the mechanisms that damage nuclear DNA in aging are insufficiently defined. Cells that migrate or reside within confined environments experience forces applied to their nucleus, leading to transi...

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Literature Corpus work: c9532467-53a1-5998-82ff-26bd28a7b8cf
DOI: 10.1101/2022.02.17.480837

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