Article

Analysis of regulatory network modules in hundreds of human stem cell lines reveals complex epigenetic and genetic factors contribute to pluripotency state differences between subpopulations

2023-05-22

Abstract excerpt

<h4>SUMMARY</h4> Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Analyzing hundreds of hiPSCs derived from different individuals, we show the proportions of these pluripotent states vary considerably across lines. We discovered 13 gene network modules (GNMs) and 13 regulatory network modules (RNMs), which were highly correlated with each other suggesting that the coordinated co-ac...

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Literature Corpus work: d4576112-3748-5748-873c-64f68c821b61
DOI: 10.1101/2023.05.20.541447

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