Article

Time- and cell-dependent atypia and cell death are caused by progressive deficiency in DNA replication

2021-01-03

Abstract excerpt

Pleiotropy caused by single-gene mutations is common and poorly understood. A zebrafish null mutant of DNA polymerase α subunit B, huli hutu ( hht) , evolves a complex pleiotropy associated with DNA damage and S phase arrest across multiple organ systems over 5-7 days, including nuclear atypia, a common cellular feature in human cancers and pre-cancers, in gastrointestinal organs, and nuclear fragmentation in th...

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Literature Corpus work: 85792749-ed25-53fe-bffa-6424d51da3e9
DOI: 10.1101/2020.12.31.425001

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