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Article

Ctdp1 deficiency leads to early embryonic lethality in mice and defects in cell cycle progression in MEFs.

Biology open - 6 Jan 2021

Qiao Fangfang, Law Henry C-H, Krieger Kimiko L, Clement Emalie J, Xiao Yi, Buckley Shannon M, Woods Nicholas T

Abstract excerpt

RNA polymerase II subunit A Carboxy-Terminal Domain Phosphatase 1 (CTDP1), a member of the haloacid dehalogenase superfamily phosphatases, has a defined role in transcriptional regulation, but emerging evidence suggests an expanded functional repertoire in the cell cycle and DNA damage response. In humans, a splice site mutation in CTDP1 gives rise to the rare Congenital Cataracts Facial Dysmorphism and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33408128
DOI: 10.1242/bio.057232
PMCID: PMC7803460

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