Article

Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determination

2022-10-21

Abstract excerpt

Deregulated DNA replication causes human developmental disorders and cancer, but we know little about how DNA replication is coordinated with changes in transcription and chromatin structure. The initiation of replication forks follows a spatiotemporal pattern called the replication timing program. We have developed the zebrafish into a model system to study the mechanisms by which the replication timing program c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1bc1a831-5765-5a3c-828f-a546f63ce1fd
DOI: 10.1101/2022.10.21.512903

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determinationDOI 10.1101/2022.10.21.512903Read

Embryonic genome instability upon DNA replication timing program emergenceSemantic proximity Read

Comprehensive analysis of DNA replication timing in genetic diseases and gene knockouts identifies <i>MCM10</i> as a novel regulator of the replication programSemantic proximity Read

Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells.Semantic proximity Read

Sex-specific DNA-replication in the early mammalian embryoSemantic proximity Read

Replication timing and transcriptional control: beyond cause and effect.Semantic proximity Read

Single cell multiomics approach to analyze replication timing and gene expression in mouse preimplantation embryosSemantic proximity Read

Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship.Semantic proximity Read

Novel Single-Cell Multiomics Approach to Analyze Replication Timing and Gene Expression in Mouse Preimplantation EmbryosSemantic proximity Read

Global early replication disrupts gene expression and chromatin conformation in a single cell cycleSemantic proximity Read

High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read

RT States: systematic annotation of the human genome using cell type-specific replication timing programsSemantic proximity Read

High Resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read