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Article

Chronic replication stress-mediated genomic instability disrupts placenta development in mice.

PLoS genetics - 1 Apr 2026

Munisha Mumingjiang, Huang Rui, Khan Jordan, Schimenti John C

Abstract excerpt

Abnormal placentation drives many pregnancy-related pathologies and poor fetal outcomes, but the underlying molecular causes are understudied. Here, we show that persistent replication stress due to mutations in the MCM2-7 replicative helicase disrupts placentation and reduces embryo viability in mice. MCM-deficient embryos exhibited normal morphology, but their placentae had a drastically diminished junctional...

Topics

Animals
Female
Genomic Instability
Mice
Pregnancy
DNA Replication
Placentation
Placenta
Trophoblasts
Cell Proliferation
DNA Helicases
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 41973757
DOI: 10.1371/journal.pgen.1012111
PMCID: PMC13099090

Genes

MCM2
FANCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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