Article

The cGAS-STING pathway is an <i>in vivo</i> modifier of genomic instability syndromes

2024-10-18

Abstract excerpt

Mutations in genes involved in DNA damage repair (DDR) often lead to premature aging syndromes. While recent evidence suggests that inflammation, alongside mutation accumulation and cell death, may drive disease phenotypes, its precise contribution to in vivo pathophysiology remains unclear. Here, by modeling Ataxia Telangiectasia (A-T) and Bloom Syndrome in the African turquoise killifish ( N. furzeri ), we rep...

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Literature Corpus work: acc1a145-a6f6-57bf-9a9c-70c63524d32e
DOI: 10.1101/2024.10.16.618655

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