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Article

ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma.

eLife - 17 Jan 2023

Morgan Kimberly J, Doggett Karen, Geng Fansuo, Mieruszynski Stephen, Whitehead Lachlan, Smith Kelly A, Hogan Benjamin M, Simons Cas, Baillie Gregory J, Molania Ramyar, Papenfuss Anthony T, Hall Thomas E, Ober Elke A, Stainier Didier Y R, Gong Zhiyuan, Heath Joan K

Abstract excerpt

The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly and mitosis. Using both larval and adult zebrafish models of hepatocellular carcinoma (HCC), in which the expression of an inducible mutant kras transgene (krasG12V) drives hepatocyte-specific hyperplasia and liver enlargement, we show that reducing ahctf1 gene dosage by 50% markedly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36648336
DOI: 10.7554/eLife.73407
PMCID: PMC9897728

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