Article
DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress.
Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2020
Wang Rui, Lenoir Walter F, Wang Chao, Su Dan, McLaughlin Megan, Hu Qianghua, Shen Xi, Tian Yanyan, Klages-Mundt Naeh, Lynn Erica, Wood Richard D, Chen Junjie, Hart Traver, Li Lei
Abstract excerpt
Fanconi anemia (FA) is caused by defects in cellular responses to DNA crosslinking damage and replication stress. Given the constant occurrence of endogenous DNA damage and replication fork stress, it is unclear why complete deletion of FA genes does not have a major impact on cell proliferation and germ-line FA patients are able to progress through development well into their adulthood. To identify potential...
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