Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biochemical Fractionation of Time-Resolved Drosophila Embryos Reveals Similar Transcriptomic Alterations in Replication Checkpoint and Histone mRNA Processing Mutants.

Journal of molecular biology - 27 Oct 2017

Lefebvre Fabio Alexis, Benoit Bouvrette Louis Philip, Bergalet Julie, Lécuyer Eric

Abstract excerpt

In higher eukaryotes, maternally provided gene products drive the initial stages of embryogenesis until the zygotic transcriptional program takes over, a developmental process called the midblastula transition (MBT). In addition to zygotic genome activation, the MBT involves alterations in cell-cycle length and the implementation of DNA damage/replication checkpoints that serve to monitor genome integrity....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Checkpoints
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Drosophila Proteins

Share to Embryo, Nonmammalian

Share to Histones

Share to Transcriptome

Share to Zygote

Source

Identifiers

PMID: 28167048
DOI: 10.1016/j.jmb.2017.01.022

Genes

SLBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biochemical Fractionation of Time-Resolved Drosophila Embryos Reveals Similar Transcriptomic Alterations in Replication Checkpoint and Histone mRNA Processing Mutants.PMID 28167048Read ↗

DNA-replication checkpoint control at the Drosophila midblastula transition.Semantic proximity Read ↗

Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression.Semantic proximity Read ↗

Molecular genetics of maternally-controlled cell divisions.Semantic proximity Read ↗

Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation.Semantic proximity Read ↗

Common and distinct transcriptional signatures of mammalian embryonic lethality.Semantic proximity Read ↗

Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis.Semantic proximity Read ↗

Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determinationSemantic proximity Read ↗

p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase delta1.Semantic proximity Read ↗

PARP-2 catalytic activity drives replication-ICL repair in an allele-specific manner during germline development.Semantic proximity Read ↗

Onset of the DNA replication checkpoint in the early Drosophila embryo.Semantic proximity Read ↗

Embryonic genome instability upon DNA replication timing program emergenceSemantic proximity Read ↗

Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.