Molecular architecture of OXGR1 reveals evolutionary conserved mechanisms for metabolite surveillance

Abstract excerpt

The ability of cells to sense and respond to metabolic signals is fundamental to life, yet the molecular mechanisms underlying metabolite surveillance remain incompletely understood. Here, we elucidate the structural basis of metabolite recognition by OXGR1, a GPCR that monitors key intermediates in the tricarboxylic acid cycle (TCA). Using cryo-electron microscopy, we determined four cryo-EM structures of OXGR1 b...

Topics

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• Binding Sites
• Cryoelectron Microscopy
• Molecular Dynamics Simulation
• Odorants
• Propionates
• Receptors, Odorant
• Smell
• Substrate Specificity

Identifiers and source

Literature Corpus work

85779316-295d-5ad1-b33c-5768df995c65

DOI

10.1101/2025.09.17.676713